Endocrine Abstracts

Background: To date, it has been established that appointment of testosterone replacement therapy (TRT) in men with type 2 diabetes mellitus (T2DM) and testosterone (T) deficiency improves control of carbohydrate metabolism. Although, studies of effectiveness of different hypoglycemic drugs in men with T2DM and T deficiency have not been conducted. The aim of this study was to compare the efficacy of various types of hypoglycemic therapy in patients with T2DM and late onset hy...

It is known that the presence of type 2 diabetes mellitus (T2DM) deteriorates the psychological status of patients, but its combination with a deficiency of testosterone (T) in men is not well studied. The aim of this work was to study the effect of T replacement therapy (TRT) on the levels of anxiety, depression, symptoms of androgen deficiency, diabetes and quality of life in men with T2DM and functional hypogonadism.Materials and methods: We examined ...

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver diseases, and the presence of type 2 diabetes mellitus (T2DM) increases its incidence up to 90%. To date, the effect of androgen deficiency in men with T2DM on the development of NAFLD has not been studied.Aim: To assess the effect of the endogenous testosterone (T) level on the incidence of NAFLD in men with T2DM.Materials and methods: The study...

Abstract: There are few studies of the cellular immunity in men with obesity and hypogonadism. The aim was to study the parameters of cellular components of the immune system in patients with obesity and hypogonadism.Materials and methods: The study included 120 men aged 40–65 years with obesity (mean BMI – 35±5.6 kg/m2). Patients were divided into two groups depending on the level of total testosterone (T). The first group incl...

Background: Men with type 2 diabetes mellitus (T2DM) have significantly lower levels of testosterone (T) than nondiabetic controls. But androgen deficit symptoms may be detected in males with normal T levels.Aim: To analyze parameters of lipid, carbohydrate metabolism and endothelial function in diabetic males with low normal and middle-to-high normative T levels.Patients and methods: We examined 86 men with T2DM and serum T levels...

Late identification and inadequate assessment of cardiovascular risk factors are being considered as the main cause of high mortality in men with type 2 diabetes mellitus (T2DM).Aim: To analyze the carbohydrate metabolism, levels of testosterone, proinflammatory cytokines in patients with T2DM and obesity.Methods: We examined 123 men with T2DM and obesity (mean age – 53.8±6.8). Parameters of carbohydrate metabolism, total...

Currently actively studied the role of certain inflammatory and proinflammatory cytokines in the pathogenesis of insulin resistance, type 2 diabetes, obesity, atherosclerosis. However, the influence of testosterone deficiency on the balance of proinflammatory cytokines is unexplored. The aim of the work was to evaluate the influence of testosterone deficiency on metabolic parameters and levels of proinflammatory cytokines in patients with obesity and type 2 diabetes.<p cla...

It is well known that type 2 diabetes causes the endothelial dysfunction. However, insufficient attention is paid to the role of androgen deficiency in the formation of the early signs of endothelial dysfunction. The aim of the work was to evaluate the relationship between testosterone deficiency and markers of endothelial dysfunction in men with type 2 diabetes.Materials and methods: Were examined 88 men aged 40–65 years with type 2 diabetes. All p...